Center of Plant Systems Biology and Biotechnology  /  Departments  / Department Plant Cell Biotechnology

Written by Ivan Dulgerov

Plant Cell Biotechnology

Plant in vitro technologies are considered as an attractive and cost-effective alternative to classical approaches (i.e., natural harvest and chemical synthesis) for the mass production of value-added plant-derived metabolites (“green factories” concept). Genetic modification in such a contained system can readily be applied without the regulatory barriers associated with field grown crops. Moreover, cell/tissue culture systems can be up-scaled in bioreactors with controllable bioproduction rates. The department closely interacts with the other CPSBB research Departments to better understand the plant biochemical machinery and to develop new means for sustainable bioproduction of high value molecules.

 

Overview of the research workflow in Plant Cell Biotechnology department

Visiting Scientists / Interns

Name Position Institution Period
Esther Campanella ERASMUS+ Trainee ITS Nuove Tecnologie della Vita – Bergamo, Italy 12.01.2026 – 16.06.2026
Internship description
Esther is currently undertaking a traineeship at the Department of Plant Cell Biotechnology at CPSBB. During the internship, she is gaining hands-on experience in plant in vitro cultures, laboratory techniques, and biological activity testing using the Caenorhabditis elegans model. Her work involves supporting laboratory testing of bioactive compounds and observing their effects on biological systems. The traineeship provides training in experimental design, data analysis, and scientific reporting, as well as teamwork in an international research environment.
Todeschini Camilla ERASMUS+ Trainee ITS Nuove Tecnologie della Vita – Bergamo, Italy 12.01.2026 – 16.06.2026
Internship description
Camilla is currently undertaking a traineeship at the Department of Plant Cell Biotechnology at CPSBB. During the internship, she is gaining hands-on experience in plant in vitro cultures, laboratory techniques, and biological activity testing using the Caenorhabditis elegans model. Her work involves supporting laboratory testing of bioactive compounds and observing their effects on biological systems. The traineeship provides training in experimental design, data analysis, and scientific reporting, as well as teamwork in an international research environment.
Giulia Farinasso MSc Student (ERASMUS+) Brno University of Technology – Brno, Czech Republic 20.11.2025 – 05.05.2026
Internship description
Giulia is currently working at her Master thesis development at both the Department of Plant Cell Biotechnology at CPSBB and the Institute of Microbiology of the Bulgarian Academy of Sciences. During her internship, she is gaining hands-on experience in laboratory techniques, and sample preparation for metabolomics using the Caenorhabditis elegans model system. Her work involves protocol adaptation for a GC-TripleQuad-MS spectra acquisition and targeted detection of metabolites. The traineeship provides training in experimental design, data analysis, and scientific reporting, as well as teamwork in an international research environment.
Vito Dolce MSc of Pharmacy (ERASMUS+) Università degli Studi della Basilicata – Potenza, Italy 08.02.2026 – 07.07.2026
Internship description
Vito is undergoing laboratory traineeship at both the Department of Plant Cell Biotechnology at CPSBB and the Institute of Microbiology of the Bulgarian Academy of Sciences. During his internship, he is gaining hands-on experience in laboratory techniques, and sample preparation for metabolomics using the Caenorhabditis elegans model system. His work involves protocol adaptation for UPLC-qToF-MS spectra acquisition and targeted detection of metabolites. The traineeship provides training in experimental design, data analysis, and scientific reporting, as well as teamwork in an international research environment.

 

2026
Krustanova S., Todorova M.N., Gerasimova V., Savova M.S., Stoyanov S., Popova M.P., Georgiev M.I., Alipieva K. (2026)
Stress endurance mediates the healthspan-promoting effect of two newly described iridoid glycosides from Verbascum nigrum ssp. abietinum in Caenorhabditis elegans.
Phytomedicine. DOI: 10.1016/j.phymed.2026.157944. • IF 8.3
Mihaylova L.V., Savova M.S., Todorova M.N., Tonova V., Binev B.K., Georgiev M.I. (2026)
Cycloastragenol improves fatty acid metabolism through NHR-49/FAT-7 suppression and potent AAK-2 activation in Caenorhabditis elegans obesity model.
International Journal of Molecular Sciences. 27(2): 772. • IF 4.9
Palankalieva A.P., Stoykova I.D., Georgiev M.I., Belcheva A.B. (2026)
Comparative cytocompatibility and oxidative stress analysis of green-synthesized nano-silver fluoride and silver diamine fluoride in human gingival fibroblasts.
Journal of Functional Biomaterials. 17(4): 195. • IF 5.2
Todorova M.N., Dyankov S., Savova M.S., Todorova V., Georgiev M.I., Ivanova S. (2026)
Echinophora tenuifolia L. subsp. sibthorpiana modulates stress response and mitochondrial quality under glucose stress in Caenorhabditis elegans.
Antioxidants. 15(3): 398. • IF 6.6
Todorova M.N., Savova M.S., Binev B.K., Georgiev M.I. (2026)
The chemically defined herbal mixture ADAPT-232 delays mitochondrial dysfunction and promotes healthspan through mitophagy-related pathways mediated by the DAF-16/NHR-49 axis.
Phytomedicine. 153: 157944. • IF 8.3
2025
Chen J., Zhang Y., Li Y., Liu Y., Li Q., Lv Z., Georgiev M.I., Liao P. (2025)
The last decade of medicinal plant genomics: Advances and challenges.
Engineering. DOI: https://doi.org/10.1016/j.eng.2025.09.024. • IF 11.6
Efferth T., Zacchino S., Georgiev M.I., He R.R., Shen X., Albrecht U., Belwal T., Bhutia S.K., Chatterjee M., Chen J., Chen Z.Y., Cho W., Devi S.I., Eid A.H., Orhan I.E., Gao Y., Hosseinzadeh H., Hua Q., Khan H.,…Yücer R. (2025)
30th Anniversary of Phytomedicine: Looking Back and Forth.
Phytomedicine. 149: 157525. • IF 8.3
Fulgheri F., Angius F., Perra M., Delogu I., Puxeddu S., Georgiev M.I., Novotná R., Franková J., Lobina M., Manzin A., Manconi M., Manca M.L. (2025)
Liposomal delivery of a biotechnological lavandula angustifolia miller extract rich in rosmarinic acid for topical herpes simplex therapy.
Antioxidants. 14(7): 811. • IF 6.6
Koycheva I.K., Stoyanova E., Todorova B., Stoykova I.D., Savova M.S., Mihaylova L.V., Mihaylova N., Georgiev M.I. (2025)
Anti-psoriatic activity of biotechnologically produced Harpagophytum procumbens extract in an imiquimod-induced psoriasiform skin inflammation model.
South African Journal of Botany. 184: 936-950. • IF 2.3
Lu X., He Y., Weng W., Liu Z., Gao Y., Shi Y., Li W., Lai D., Zhao M., Jha R., Zhao H., Li G., Guan C., Shao S., Ruan J., Woo S.H., Ouyang Y., Quinet M., Georgiev M.I., Fernie A.R., Hou C., Zhang K., Liu X., Zhou M. (2025)
Domestication of tartary buckwheat shaped a regulatory module for seedling salt tolerance by targeting the magnesium transporter gene FtMGT2.
Advanced Science. DOI: https://doi.org/10.1002/advs.202511570. • IF 14.1
Maciejewska-Turska M, Georgiev M.I., Kai G., Sieniawska E. (2025)
Advances in bioinformatic methods for the acceleration of the drug discovery from nature.
Phytomedicine. 139: 156518. • IF 8.3
Priboyska K., Todorova M.N., Gerasimova V.I., Savova M.S., Krustanova S., Petkova Z., Stoyanov S., Popova M.P., Georgiev M.I., Alipieva K. (2025)
Phytochemical Profiling and Anti-Obesogenic Potential of Scrophularia aestivalis Griseb. (Scrophulariaceae).
Molecules. 30(21): 4202. • IF 4.6
Rojo A.I., Buttari B., Cadenas S., Carlos A.R., Cuadrado A., Falcão A.S., López M.G., Georgiev M.I., Grochot-Przeczek A., Gumeni S., Jimenez-Villegas J., Horbanczuk J.O., Konu O., Lastres-Becker I., Levonen A.L., Maksimova V., Michaeloudes C., Mihaylova L.V., Mickael M.E., Milisav I., Miova B., Rada P., Santos M., Seabra M.C., Strac D.S., Tenreiro S., Trougakos I.P., Dinkova-Kostova A.T. (2025)
Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.
Redox Biology. 79: 103464. • IF 11.9
Savova M.S., Todorova M.N., Binev B.K., Georgiev M.I., Mihaylova L.V. (2025)
Curcumin enhances the anti-obesogenic activity of orlistat through SKN-1/NRF2-dependent regulation of nutrient metabolism in Caenorhabditis elegans.
International Journal of Obesity. 49(3): 516–526. • IF 3.8
Stoykova I.D., Koycheva I.K., Binev B.K., Mihaylova L.V., Georgiev M.I. (2025)
Molecular approaches to prevent UV-induced premature skin aging: Focus on phytochemicals as photo-protectants.
Phytochemistry Reviews. 24(1): 119–150. • IF 7.6
Todorova V., Todorova M.N., Savova M.S., Ivanov K., Georgiev M.I., Ivanova S. (2025)
Maral root extract and its main constituent 20-Hydroxyecdysone enhance stress resilience in Caenorhabditis elegans.
International Journal of Molecular Sciences. 26(8): 3739. • IF 4.9
Wang S., Zhang X., Gong D.H., Huang Q.Q., Kandegama W., Georgiev M.I., Gao Y.Y., Liao P., Hao G.F. (2025)
Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses.
Plant Communications. 6(9): 101425. • IF 11.6
2024
Huang X., He Y., Zhang K., Shi Y., Zhao H., Lai D., Lin H., Wang X., Yang Z., Xiao Y., Li W., Ouyang Y., Woo S.H., Quinet M., Georgiev M.I., Fernie A.R., Liu X., Zhou M. (2024)
Evolution and domestication of a novel biosynthetic gene cluster contributing to the flavonoid metabolism and high-altitude adaptability of plants in the Fagopyrum genus.
Advanced Science. 11(43): e2403603. • IF 14.1
Jha R., Zhang K., He Y., Mendler-Drienyovszki N., Magyar-Tábori K., Quinet M., Germ M, Kreft I., Meglič V., Ikeda K., Chapman M.A., Janovská D., Podolska G., Woo S.-H., Bruno S., Georgiev M.I., Chrungoo N., Betekhtin A., Zhou M. (2024)
Global nutritional challenges and opportunities: Buckwheat, a potential bridge between nutrient deficiency and food security.
Trends in Food Science and Technology. 145: 104365 • IF 15.4
Kozuharova E., Pasdaran A., Hamedi A., Batovska D., Georgiev M.I., Marchev A., Attard E., Gibernau M. (2024)
Bioactive compounds and biological activities of Arum L.. In: Murthy H.N., Paek K.Y., Park SY. (Eds.)
Bioactive compounds in the storage organs of plants. Reference series in phytochemistry. Springer. Cham. pp. 105-138. (ISBN: 978-3-031-44746-4)
Lai D., Zhang K., He Y., Fan Y., Li W., Shi Y., Gao Y., Huang X., He J., Zhao H., Lu X., Xiao Y., Cheng J., Ruan J., Georgiev M.I., Fernie A., Zhou M. (2024)
Multi-omics identification of a key glycosyl hydrolase gene FtGH1 involved in rutin hydrolysis in Tartary buckwheat (Fagopyrum tataricum).
Plant Biotechnology Journal. 5: 1206-1223. • IF 10.5
Marchev A.S., Stoykova I.D., Georgiev M.I. (2024)
Large-scale production of specialized metabolites in vitro cultures. In: Loyola-Vargas V., Ochoa-Alejo N. (Eds.)
Plant cell culture protocols. Methods in molecular biology. vol 2827. Humana, New York, NY, USA. pp. 303-322.
Stoykova I.D, Koycheva I., Binev B., Mihaylova L.V., Benina M., Alipieva K., Georgiev M.I. (2024)
Myconoside and calceolarioside E restrain UV-Induced skin photoaging by activating NRF2-mediated defense mechanisms.
International Journal of Molecular Sciences. 25(4): 2441. • IF 5.6
Stoykova I.D, Koycheva I.K., Binev B.K., Mihaylova L.V., Georgiev M.I. (2024)
Molecular approaches to prevent UV-induced premature skin aging: Focus on phytochemicals as photo-protectants.
Phytochemistry Reviews. • IF 7.4
Todorova M.N., Savova M.S., Mihaylova L.V., Georgiev M.I. (2024)
Icariin improves stress resistance and extends lifespan in Caenorhabditis elegans through hsf-1 and daf-2-driven hormesis.
International Journal of Molecular Sciences. 25(1): 352. • IF 4.9
Todorova M.N., Savova, M.S., Mihaylova L.V., Georgiev, M.I. (2024)
Nurturing longevity through natural compounds: Where do we stand, and where do we go?
Food Frontiers. 5(2): 267-310. • IF 6.9
Todorova M.N., Savova M.S., Mihaylova L.V., Georgiev M.I. (2024)
Punica granatum L. leaf extract enhances stress tolerance and promotes healthy longevity through HLH-30/TFEB, DAF16/FOXO, and SKN1/NRF2 crosstalk in Caenorhabditis elegans.
Phytomedicine. 134: 155971. • IF 8.3
Yang Z., Tan D., Chen W., Hu J., Huang R., Wu X., Georgiev M.I., Bai W., Tian L. (2024)
Fermentation characteristics and prebiotic potential of enzymatically synthesized butyryl-fructooligosaccharides.
Carbohydrate Polymers. 324: 121486. • IF 12.5
Yaneva T.G., Wiczkowski W., Marchev A.S., Iserliyska D., Georgiev M.I., Tomlekova N.B. (2024)
Evaluation of polyphenols synthesized in mature seeds of common bean (Phaseolus vulgaris L.) advanced mutant lines.
International Journal of Molecular Science. 25(11): 5638. • IF 4.9
2023
Ali K., Georgiev M.I. (2023)
Editorial: Omics and its integration: a systems biology approach to understanding plant physiology.
Frontiers in Plant Science. 14: 1324901. • IF 4.1
Amirova K., Dimitrova P., Leseva M., Koycheva I., Dinkova-Kostova Albena., Georgiev M.I. (2023)
The triterpenoid Nrf2 Activator, CDDO-Me, decreases neutrophil senescence in a murine model of joint damage.
International Journal of Molecular Sciences. 24(10): 8775. • IF 4.9
Boneva B., Marchev A., Amirova K., Ganova P., Georgiev M.I., Tchorbanov A., Mihaylova N. (2023)
Crocus sativus extract as a biological agent for disease-modifying therapy of collagenase-induced mouse model of osteoarthritis.
Life. 13(4): 894. • IF 3.2
Chen C., Zhang K., Liu F., Wang X., Yao Y., Niu X., He Y., Hong J., Liu F., Gao Q., Zhang Y., Li Y., Wang M., Lin J., Fan Y., Ren K., Shen L., Gao B., Ren X., Yang W., Georgiev M.I., Zhang X., Zhou M. (2023)
Resequencing of global Lotus corniculatus accessions reveals population distribution and genetic loci, associated with cyanogenic glycosides accumulation and growth traits.
BMC Biology. 21: 176. • IF 4.4
He Y., Zhang K., Li S., Lu X., Zhao H., Guan C., Huang X., Shi Y., Kang Z., Fan Y., Li W., Chen C., Li G., Long O., Chen Y., Hu M., Cheng J., Xu B., Chapman M.A., Georgiev M.I., Fernie A.R., Zhou M. (2023)
Multiomics analysis reveals the molecular mechanisms underlying virulence in Rhizoctonia and JA-mediated resistance in Tartary buckwheat(Fagopyrum tataricum).
The Plant Cell. 35(8): 2773-2798. • IF 10.0
Huda, M. N., Li, X., Jahan, T., He, Y., Guan, C., Zhang K., Gao A., Georgiev M.I., Zhou M. (2023)
Acceleration of the genetic gain for nutraceutical improvement of adlay (Coix L.) through genomic approaches: current status and future prospects.
Food Reviews International. 39(8): 5377-5401. • IF 6.043
Ivanova T., Marchev A., Chervenkov M., Bosseva Y., Georgiev M.I., Kozuharova E., Dimitrova D. (2023)
Catching the green-Diversity of ruderal spring plants traditionally consumed in Bulgaria and their potential benefit for human health.
Diversity. 15(3): 435. • IF 2.1
Koycheva I.K., Marchev A.S., Stoykova I.D., Georgiev M.I. (2023)
Natural alternatives targeting psoriasis pathology and key signaling pathways: a focus on phytochemicals.
Phytochemistry Reviews. (in press). DOI: 10.1007/s11101-023-09886-9 • IF 7.3
Mladenova S.G., Todorova M.N., Savova M.S., Mihaylova L.V., Georgiev M.I. (2023)
Maackiain mimics caloric restriction through aak-2-mediated lipid reduction in Caenorhabditis elegans.
International Journal of Molecular Sciences. 24(24): 17442. • IF 4.9
Savova M.S., Mihaylova L.V., Tews D., Wabitsch M., Georgiev M.I. (2023)
Targeting PI3K/akt signaling pathway in obesity.
Biomedicine and Pharmacotherapy. 159: 114244. • IF 6.9
Todorova V., Savova M.S., Ivanova, S., Ivanov K., Georgiev M.I. (2023)
Anti-adipogenic activity of Rhaponticum carthamoides and its secondary metabolites.
Nutrients. 15: 3061. • IF 4.8
Zhang K., He Y., Lu X., Shi Y., Zhao H., Li X., Li J., Liu Y., Ouyang Y., Tang Y., Ren X., Zhang X., Yang W., Sun Z., Zhang C., Quinet M., Luthar Z., Germ M., Kreft I., Janovska D., Meglic V., Pipan B., Georgiev M.I., Bruno S., Chapman M.A. Zhou M. (2023)
Comparative and population genomics of buckwheat species reveal key determinants of flavor and fertility.
Molecular Plant. 16(9): 1427-1444. • IF 27.5
Zhao H., He Y., Zhang K., Li S., Chen Y., He M., He F., Gao B., Yang D., Fan Y., Zhu X., Yan M., Giglioli-Guivarc’h N., Hano C., Fernie A.R., Georgiev M.I., Janovska D., Meglic V., Zhou M. (2023)
Rewiring of the seed metabolome during Tartary buckwheat domestication.
Plant Biotechnology Journal. 21(1): 150-164. • IF 13.263
2022
Chen C., Liu F., Zhang K., Niu X., Zhao H., Liu Q., Georgiev M.I., Xu X., Zhang X., Zhou M. (2022)
MeJA-responsive bHLH transcription factor LjbHLH7 regulates cyanogenic glucoside biosynthesis in lotus japonicus.
Journal of Experimental Botany. 73(8): 2650-2665. • IF 7.298
Ding M., He Y., Zhang K., Li J., Shi Y., Zhao M., Meng Y., Georgiev M.I., Zhou M. (2022)
JA-induced FtBPM3 accumulation promotes FtERF-EAR3 degradation and rutin biosynthesis in Tartary buckwheat.
Plant Journal. 112(2): 323-334. • IF 7.091
He M., He Y., Zhang K., Lu X., Zhang X., Gao B., Fan Y., Zhao H., Jha R., Huda M.N., Tang Y., Wang J., Yang W., Yan M., Cheng J., Ruan J., Dulloo E., Zhang Z., Georgiev M.I., Chapman M., Zhou M. (2022)
Comparison of buckwheat genomes reveals the genetic basis of metabolomic divergence and ecotype differentiation.
New Phytologist. 235(5): 1927-1943. • IF 10.323
Liu J., Wang Y., Wu J., Georgiev M.I., Xu B., Wong K.H., Bai W., Tian L. (2022)
Isolation, structural properties, and bioactivities of polysaccharides from mushrooms termitomyces: a review.
Journal of Agricultural and Food Chemistry. 70(1): 21-33. • IF 5.895
Marchev A., Amirova K., Georgiev M.I. (2022)
Genetic engineering of cell cultures for enhanced production of nutraceuticals. In T. Belwal, M.I. Georgiev, & J.M. Al-Khayri (Eds.).
Nutraceuticals Production from Plant Cell Factory. (pp. 395-415). Springer, Singapore.
Mladenova S.G., Savova M.S., Marchev A.S., Ferrante C., Orlando G., Wabitsch M., Georgiev M.I. (2022)
Anti-adipogenic activity of maackiain and ononin is mediated via inhibition of PPARγ in human adipocytes.
Biomedicine and Pharmacotherapy. 149: 112908. • IF 7.419
Perra M., Fancello L., Castangia I., Allaw M., Escribano-Ferrer E., Peris J.E., Usach I., Manca M.L., Koycheva I.K., Georgiev M.I., Manconi M. (2022)
Formulation and testing of antioxidant and protective effect of hyalurosomes loading extract rich in rosmarinic acid biotechnologically produced from Lavandula angustifolia miller.
Molecules. 27(8): 2423. • IF 4.927
Savova M.S., Todorova M.N., Apostolov A.G., Yahubyan G.T., Georgiev M.I. (2022)
Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression.
Biomedicine and Pharmacotherapy. 156: 113862 • IF 7.419
Sieniawska E., Georgiev M.I. (2022)
Metabolomics: towards acceleration of antibacterial plant-based leads discovery.
Phytochemistry Reviews. 21: 765-781. • IF 7.741
Zhou W., Georgiev M.I., Liao P. (2022)
Editorial: Discovery, biosynthesis, regulation, transport, release and engineering of plant natural products.
Frontiers in Plant Science. 13:1017808. • IF 6.627
2021
Amirova K.M., Dimitrova P.A., Marchev A.S., Krustanova S., Simova S., Alipieva K., Georgiev M.I. (2021)
Biotechnologically-produced myconoside and calceolarioside E induce Nrf2-expression in neutrophils.
International Journal of Molecular Sciences. 22(4): 1759. • IF 6.208
Atanasov A.G., Zotchev S.B., Dirsch V.M., Orhan I.E., Banach M., Rollinger J.M., Barreca D., Weckwerth W., Bauer R., Bayer E.A., Majeed M., Bishayee A., Bochkov V., Bonn G.K., Braidy N., Bucar F., Cifuentes A., D’Onofrio G., Bodkin M., Diederich M., Dinkova-Kostova A.T., Efferth T., El Bairi K., Arkells N., Fan T-P., Fiebich B.L., Freissmuth M., Georgiev M.I. et al. (2021)
Natural products in drug discovery: advances and opportunities.
Nature Reviews Drug Discovery. 20: 200-216. • IF 112.288
Ding M., Zhang K., He Y., Zuo Q., Zhao H., He M., Georgiev M.I., Park S.U., Zhou M. (2021)
FtBPM3 modulates the orchestration of FtMYB11-mediated flavonoids biosynthesis in Tartary buckwheat.
Plant Biotechnology Journal. 19(7): 1285-1287. • IF 13.263
Georgiev M.I., Vasileva L.V., Savova M.S. (2021)
Antiobesity molecules of natural origin: Call for lead finding acceleration.
Food Frontiers. 2(1): 23-24.
He Y., Zhang K., Georgiev M.I., Zhou M. (2021)
Ubiquitin proteins and the orchestration of transcription factors activity.
Critical Reviews in Plant Sciences. 40(4): 366-377. • IF 6.289
Huda N.Md., Lu S., Jahan T., Ding M., Jha R., Zhang K., Zhang W., Georgiev M.I., Park S-U., Zhou M. (2021)
Treasure from garden: bioactive compounds of buckwheat.
Food Chemistry. 335: 127653. • IF 9.231
Koycheva I.K., Mihaylova L.V., Todorova M.N., Balcheva-Sivenova Z.P., Alipieva K., Ferrante C., Orlando G., Georgiev M.I. (2021)
Leucosceptoside A from Devil’s Claw modulates psoriasis-like inflammation via suppression of the PI3K/AKT signaling pathway in keratinocytes
Molecules. 26: 7014. • IF 4.927
Koycheva I.K., Vasileva L.V., Amirova K.M., Marchev A.S., Balcheva-Sivenova Z.P., Georgiev M.I. (2021)
Biotechnologically-produced Lavandula angustifolia Mill. extract rich in rosmarinic acid resolves psoriasis-related inflammation through JAK/STAT signaling.
Frontiers in Pharmacology. 12: 680168. • IF 5.988
Li J., Meng Y., Zhang K., Li Q., Li S., Xu B., Georgiev M.I., Zhou M. (2021)
Jasmonic acid-responsive RRTF1 transcription factor controls DTX18 gene expression in hydroxycinnamic acid amide secretion
Plant Physiology. 185(2): 369–384. • IF 8.005
Marchev A.S., Vasileva L.V., Amirova K.M., Savova M.S., Koycheva I.K., Balcheva-Sivenova Z.P., Vasileva S.M., Georgiev M.I. (2021)
Rosmarinic acid – from bench to valuable applications in food industry.
Trends in Food Science and Technology. 117: 182-193. • IF 16.002
Marchev A.S., Vasileva L.V., Amirova K.M., Savova M.S., Balcheva-Sivenova Z.P., Georgiev M.I. (2021)
Metabolomics and health: from nutritional crops and plant-based pharmaceuticals to profiling of human biofluids.
Cellular and Molecular Life Sciences. 78: 6487–6503 • IF 9.237
Mladenova S.G., Vasileva L.V., Savova M.S., Marchev A.S., Tews D., Wabitsch M., Ferrante C., Orlando G., Georgiev M.I. (2021)
Anti-adipogenic effect of Alchemilla monticola is mediated via PI3K/AKT signaling inhibition in human adipocytes
Frontiers in Pharmacology. 12: 707507 • IF 5.988
Savova M.S., Vasileva L.V., Mladenova S.G., Amirova K.M., Ferrante C., Orlando G., Wabitsch M., Georgiev M.I. (2021)
Ziziphus jujuba Mill. leaf extract restrains adipogenesis by targeting PI3K/AKT signaling pathway.
Biomedicine and Pharmacotherapy. 141: 111934. • IF 7.419
Sieniawska E., Sawicki R., Marchev A.S., Truszkiewicz W., Georgiev M.I. (2021)
Tanshinones from Salvia miltiorrhiza inhibit Mycobacterium tuberculosis via disruption of the cell envelope surface and oxidative stress.
Food and Chemical Toxicology. 156: 112405. • IF 5.572
Sieniawska E., Sawicki R., Truszkiewicz W., Marchev A.S., Georgiev M.I. (2021)
Usnic acid treatment changes the composition of Mycobacterium tuberculosis cell envelope and alters bacteria redox status.
mSystems. 6(3): e00097-21. • IF 7.331
Vasileva L.V., Savova M.S., Tews D., Wabitsch M., Georgiev M.I. (2021)
Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes.
Food and Chemical Toxicology. 149: 112202. • IF 5.572
Shi M., Liao P., Nile S.H., Georgiev M.I., Kai G. (2021)
Biotechnological exploration of transformed root culture for value-added products
Trends in Biotechnology. 39(2): 137-149. • IF 21.942
Zhang K., He M., Fan Y., Zhao H., Gao B., Yang K., Li F., Tang Y., Gao Q., Lin T., Quinet M., Janovska D., Meglič V., Kwiatkowski J., Romanova O., Chrungoo N., Suzuki T., Luthar Z., Germ M., Woo S-H., Georgiev M.I., Zhou M. (2021)
Resequencing of global Tartary buckwheat accessions reveals multiple domestication events and key loci associated with agronomic traits
Genome Biology. 22: 23. • IF 18.011
Li J., Meng Y., Zhang K., Li Q., Li S., Xu B., Georgiev M.I., Zhou M. (2021)
Jasmonic acid-responsive RRTF1 transcription factor controls DTX18 gene expression in hydroxycinnamic acid amide secretion
Plant Physiology. 185(2): 369–384. • IF 8.340
2020
Belwal T., Singh G., Jeandet P., Pandey A., Giri L., Ramola S., Bhatt I.D., Venskutonis P.R., Georgiev M.I., Clement C., Luo Z. (2020)
Anthocyanins, multi-functional natural products of industrial relevance: recent biotechnological advances
Biotechnology Advances. 43: 107600. • IF 14.227
Gechev T., Georgiev M.I., Fernie A.R. (2020)
PlantaSyst: Teaming-up for systems biology and biotechnology
Trends in Plant Science. 25(7): 621-624. • IF 18.313
Joshi D.C., Zhang K., Wang C., Chandora R., Khurshid M., Li J., He M., Georgiev M.I., Zhou M. (2020)
Strategic enhancement of genetic gain for nutraceutical development in buckwheat: A Genomics-driven perspective
Biotechnology Advances. 39: 107479. • IF 14.227
Marchev A., Yordanova Z.P., Georgiev M.I. (2020)
Green (cell) factories for advanced production of plant secondary metabolites
Critical Reviews in Biotechnology. 40(4): 443-458. • IF 8.429
Sieniawska E., Golus J., Sawicki R., Georgiev M.I. (2020)
Untargeted metabolomic exploration of Mycobacterium tuberculosis stress response to cinnamon essential oil
Biomolecules. 10(3): 357. • IF 4.879
Vasileva L., Savova M., Amirova K., Balcheva-Sivenova Zh., Ferrante C., Orlando G., Wabitsch M. , Georgiev M.I. (2020)
Caffeic and chlorogenic acids synergistically activate browning program in human adipocytes: Implications of AMPK and PPAR-mediated Pathways
International Journal of Molecular Sciences. 21(24): 9740. • IF 5.924
Vasileva L., Savova M., Amirova K., Dinkova-Kostova A., Georgiev M.I. (2020)
Obesity and NRF2-mediated cytoprotection: Where is the missing link?
Pharmacological Research. 156: 104760. • IF 7.658
Wu L., Georgiev M.I., Cao H., Nahar L., El-Seedi H.R., Sarker S.D., Xiao J., Lu B. (2020)
Therapeutic potential of phenylethanoid glycosides: a systematic review
Medicinal Research Reviews. 40(6): 2605-2649. • IF 12.994
2019
Amirova K., Dimitrova P., Marchev A.S., Aneva I.Y., Georgiev M.I. (2019)
Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils
Food and Chemical Toxicology. 124: 1–9. • IF 3.775
Chen C., Zhang K., Khurshid M., Li J., He M., Georgiev M.I. , Zhang X. & Zhou M. (2019)
MYB Transcription repressors regulate plant secondary metabolism
Critical Reviews in Plant Sciences. 38: 159-170. • IF 4.189
Vasileva L., Ivanovska M., Murdjeva M., Saracheva K., Georgiev M. (2019)
Immunoregulatory natural compounds in stress-induced depression: An alternative or an adjunct to conventional antidepressant therapy?
Food and Chemical Toxicology. 127: 81–88. • IF 3.775
 
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