- Written by Dimitar Kirkovski
Plant Cell Biotechnology
Plant in vitro technologies are considered as an attractive and cost-effective alternative to classical approaches (i.e., natural harvest and chemical synthesis) for the mass production of value-added plant-derived metabolites (“green factories” concept). Genetic modification in such a contained system can readily be applied without the regulatory barriers associated with field grown crops. Moreover, cell/tissue culture systems can be up-scaled in bioreactors with controllable bioproduction rates. The department closely interacts with the other CPSBB research Departments to better understand the plant biochemical machinery and to developm new means for sustainable bioproduction of high value molecules.
| Head of Department: | ||
| Prof. Dr. Milen Georgiev | milengeorgiev@gbg.bg | |
| Members: | ||
| Dr. Liliya Vasileva | vasileva@cpsbb.eu | |
| Kristiana Amirova | amirova@cpsbb.eu | |
| Martina Savova | msavova@cpsbb.eu |
Publications:
2021
Amirova K.M., Dimitrova P.A., Marchev A.S., Krustanova S., Simova S., Alipieva K., Georgiev M.I. (2021) Biotechnologically-produced myconoside and calceolarioside E induce Nrf2-expression in neutrophils. International Journal of Molecular Sciences. 22(4): 1759.(IF 4.556)
Atanasov A.G., Zotchev S.B., Dirsch V.M., Orhan I.E., Banach M., Rollinger J.M., Barreca D., Weckwerth W., Bauer R., Bayer E.A., Majeed M., Bishayee A., Bochkov V., Bonn G.K., Braidy N., Bucar F., Cifuentes A., D’Onofrio G., Bodkin M., Diederich M., Dinkova-Kostova A.T., Efferth T., El Bairi K., Arkells N., Fan T-P., Fiebich B.L., Freissmuth M., Georgiev M.I. et al. (2021) Natural products in drug discovery: advances and opportunities. Nature Reviews in Drug Discovery. DOI: 10.1038/s41573-020-00114-z (IF 64.797)
Ding M., Zhang K., He Y., Zuo Q., Zhao H., He M., Georgiev M.I., Park S.U., Zhou M. (2021) FtBPM3 modulates the orchestration of FtMYB11-mediated flavonoids biosynthesis in Tartary buckwheat. Plant Biotechnology Journal. (accepted). (IF 8.154)
Georgiev M.I., Vasileva L.V., Savova M.S. (2021) Antiobesity molecules of natural origin: Call for lead finding acceleration. Food Frontiers. DOI: 10.1002/fft2.59.
Huda N.Md., Lu S., Jahan T., Ding M., Jha R., Zhang K., Zhang W., Georgiev M.I., Park S-U., Zhou M. (2021) Treasure from garden: bioactive compounds of buckwheat. Food Chemistry. 335: 127653 (IF 6.306)
Marchev A.S., Vasileva L.V., Amirova K.M., Savova M.S., Koycheva I.K., Balcheva-Sivenova Z.P., Vasileva S.M., Georgiev M.I. (2021) Rosmarinic acid – from bench to valuable applications in food industry. Trends in Food Science and Technology. (accepted). (IF 11.077)
Vasileva L.V., Savova M.S., Tews D., Wabitsch M., Georgiev M.I. (2021) Rosmarinic acid attenuates obesity and obesity-related inflammation in human adipocytes. Food and Chemical Toxicology. 149: 112202. (IF 4.679)
Zhang K., He M., Fan Y., Zhao H., Gao B., Yang K., Li F., Tang Y., Gao Q., Lin T., Quinet M., Janovska D., Meglič V., Kwiatkowski J., Romanova O., Chrungoo N., Suzuki T., Luthar Z., Germ M., Woo S-H., Georgiev M.I., Zhou M. (2021) Resequencing of global Tartary buckwheat accessions reveals multiple domestication events and key loci associated with agronomic traits. Genome Biology. 22: 23. (IF 10.806)
2020
Belwal T., Singh G., Jeandet P., Pandey A., Giri L., Ramola S., Bhatt I.D., Venskutonis P.R., Georgiev M.I., Clement C., Luo Z. (2020) Anthocyanins, multi-functional natural products of industrial relevance: recent biotechnological advances. Biotechnology Advances. 43: 107600. (IF 10.744)
Gechev T., Georgiev M.I., Fernie A. (2020) PlantaSyst: Teaming-up for systems biology and biotechnology. Trends in Plant Science. 25(7): 621-624. (IF 14.416)
Joshi D.C., Zhang K., Wang C., Chandora R., Khurshid M., Li J., He M., Georgiev M.I., Zhou M. (2020) Strategic enhancement of genetic gain for nutraceutical development in buckwheat: A Genomics-driven perspective. Biotechnology Advances. 39: 107479. (IF 10.744)
Li J., Meng Y., Zhang K., Li Q., Li S., Xu B., Georgiev M.I., Zhou M. (2020) Jasmonic acid-responsive RRTF1 transcription factor controls DTX18 gene expression in hydroxycinnamic acid amide secretion. Plant Physiology. DOI: 10.1093/plphys/kiaa043. (IF 6.902)
Marchev A., Yordanova Z.P., Georgiev M.I. (2020) Green (cell) factories for advanced production of plant secondary metabolites. Critical Reviews in Biotechnology. 40(4): 443-458. (IF 8.108)
Shi M., Liao P., Nile S.H., Georgiev M.I., Kai G. (2020) Biotechnological exploration of transformed root culture for value-added products. Trends in Biotechnology. DOI: 10.1016/j.tibtech.2020.06.012 (IF 14.343)
Sieniawska E., Golus J., Sawicki R., Georgiev M.I. (2020) Untargeted metabolomic exploration of Mycobacterium tuberculosis stress response to Cinnamon Essential Oil. Biomolecules. 10(3): 357. (IF 4.082)
Vasileva L., Savova M., Amirova K., Balcheva-Sivenova Zh., Ferrante C., Orlando G., Wabitsch M. , Georgiev M.I. (2020) Caffeic and chlorogenic acids synergistically activate browning program in human adipocytes: Implications of AMPK and PPAR-mediated Pathways. International Journal of Molecular Sciences. 21: 9740. (IF 4.556)
Vasileva L., Savova M., Amirova K., Dinkova-Kostova A., Georgiev M.I. (2020) Obesity and NRF2-mediated cytoprotection: Where is the missing link? Pharmacological Research. 156: 104760. (IF 5.893)
Wu L., Georgiev M.I., Cao H., Nahar L., El-Seedi H.R., Sarker S.D., Xiao J., Lu B. (2020) Therapeutic potential of phenylethanoid glycosides: a systematic review. Medicinal Research Reviews. 40(6): 2605-2649. (IF 9.3)
2019
Amirova K., Dimitrova P., Marchev A.S., Aneva I.Y., Georgiev M.I. (2019) Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils. Food and Chemical Toxicology. 124: 1–9. (IF 3.775)
Chen C., Zhang K., Khurshid M., Li J., He M., Georgiev M.I. , Zhang X. & Zhou M. (2019) MYB Transcription repressors regulate plant secondary metabolism. Critical Reviews in Plant Sciences. 38: 159-170. (IF 4.189)
Vasileva L., Ivanovska M., Murdjeva M., Saracheva K., Georgiev M. (2019) Immunoregulatory natural compounds in stress-induced depression: An alternative or an adjunct to conventional antidepressant therapy? Food and Chemical Toxicology. 127: 81–88. (IF 3.775)
