- Written by Dimitar Kirkovski
Plant Cell Biotechnology
Plant in vitro technologies are considered as an attractive and cost-effective alternative to classical approaches (i.e., natural harvest and chemical synthesis) for the mass production of value-added plant-derived metabolites (“green factories” concept). Genetic modification in such a contained system can readily be applied without the regulatory barriers associated with field grown crops. Moreover, cell/tissue culture systems can be up-scaled in bioreactors with controllable bioproduction rates. The department closely interacts with the other CPSBB research Departments to better understand the plant biochemical machinery and to developm new means for sustainable bioproduction of high value molecules.
| Head of Department: | ||
| Assoc. Prof. Dr. Milen Georgiev | milengeorgiev@gbg.bg | |
| Members: | ||
| Dr. Liliya Vasileva | vasileva@cpsbb.eu | |
| Kristiana Amirova | amirova@cpsbb.eu | |
| Martina Savova | msavova@cpsbb.eu |
Publications:
2020
Belwal T., Singh G., Jeandet P., Pandey A., Giri L., Ramola S., Bhatt I.D., Venskutonis P.R., Georgiev M.I., Clement C., Luo Z. (2020) Anthocyanins, multi-functional natural products of industrial relevance: recent biotechnological advances. Biotechnology Advances. 43: 107600. (IF 10.744)
Gechev T., Georgiev M.I., Fernie A. (2020) PlantaSyst: Teaming-up for systems biology and biotechnology. Trends in Plant Science. 25(7): 621-624. (IF 14.416)
Joshi D.C., Zhang K., Wang C., Chandora R., Khurshid M., Li J., He M., Georgiev M.I., Zhou M. (2020) Strategic enhancement of genetic gain for nutraceutical development in buckwheat: A Genomics-driven perspective. Biotechnology Advances. 39: 107479. (IF 10.744)
Marchev A., Yordanova Z.P., Georgiev M.I. (2020) Green (cell) factories for advanced production of plant secondary metabolites. Critical Reviews in Biotechnology. 40(4): 443-458. (IF 8.108)
Shi M., Liao P., Nile S.H., Georgiev M.I., Kai G. (2020) Biotechnological exploration of transformed root culture for value-added products. Trends in Biotechnology. DOI: 10.1016/j.tibtech.2020.06.012 (IF 14.343)
Sieniawska E., Golus J., Sawicki R., Georgiev M.I. (2020) Untargeted metabolomic exploration of Mycobacterium tuberculosis stress response to Cinnamon Essential Oil. Biomolecules. 10(3): 357. (IF 4.082)
Vasileva L., Savova M., Amirova K., Dinkova-Kostova A., Georgiev M.I. (2020) Obesity and NRF2-mediated cytoprotection: Where is the missing link? Pharmacological Research. 156: 104760. (IF 5.893)
2019
Amirova K., Dimitrova P., Marchev A.S., Aneva I.Y., Georgiev M.I. (2019) Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils. Food and Chemical Toxicology. 124: 1–9. (IF 3.775)
Chen C., Zhang K., Khurshid M., Li J., He M., Georgiev M.I. , Zhang X. & Zhou M. (2019) MYB Transcription repressors regulate plant secondary metabolism. Critical Reviews in Plant Sciences. 38: 159-170. (IF 4.189)
Vasileva L., Ivanovska M., Murdjeva M., Saracheva K., Georgiev M. (2019) Immunoregulatory natural compounds in stress-induced depression: An alternative or an adjunct to conventional antidepressant therapy? Food and Chemical Toxicology. 127: 81–88. (IF 3.775)
